Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts
نویسندگان
چکیده
منابع مشابه
Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling
Sclerosteosis is a rare high bone mass disease that is caused by inactivating mutations in the SOST gene. Its gene product, Sclerostin, is a key negative regulator of bone formation and might therefore serve as a target for the anabolic treatment of osteoporosis. The exact molecular mechanism by which Sclerostin exerts its antagonistic effects on Wnt signaling in bone forming osteoblasts remain...
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The loss of the SOST gene product sclerostin leads to sclerosteosis characterized by high bone mass. In this report, we found that sclerostin could antagonize canonical Wnt signaling in human embryonic kidney A293T cells and mouse osteoblastic MC3T3 cells. This sclerostin-mediated antagonism could be reversed by overexpression of Wnt co-receptor low density lipoprotein receptor-related protein ...
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The realization that Wnt signaling was critical to bone strength came to those in the bone field suddenly and from several directions. Whereas a search of ASBMR (American Society for Bone and Mineral Research) abstracts about Wnt, LRP5 (low-density-lipoprotein-receptor-related protein 5), or Dickkopf (Dkk) returned a void in 2000, there were 111 reports at the most recent meetings. The various ...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2010
ISSN: 0730-2312,1097-4644
DOI: 10.1002/jcb.22559